A carotenoid with diverse biological activities
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Norbixin (hydrate)

Item No. 40132

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,8,13,17-tetramethyl-2E,4E,6E,8E,10E,12E,14E,16E,18E-eicosanonaenedioic acid, hydrate
Molecular Formula
C24H28O4 • XH2O
Formula Weight
380.5
Purity
≥70%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly solubleTHF: Slightly soluble
SMILES
OC(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(O)=O)=O
InChi Code
InChI=1S/C24H28O4/c1-19(11-7-13-21(3)15-17-23(25)26)9-5-6-10-20(2)12-8-14-22(4)16-18-24(27)28/h5-18H,1-4H3,(H,25,26)(H,27,28)/b6-5+,11-7+,12-8+,17-15+,18-16+,19-9+,20-10+,21-13+,22-14+
InChi Key
ZVKOASAVGLETCT-UOGKPENDSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Norbixin is a carotenoid that has been found in B. orellana and has diverse biological activities.1,2,3,4 It binds to peroxisome proliferator-activated receptor γ (PPARγ) in a cell-free assay (Ki = 1.15 µM).1 Norbixin (47.7 mg/kg) attenuates hyperglycemia, hyperinsulinemia, and insulin resistance, as well as decreases serum lipid levels and cardiac levels of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) in a rat model of cardio-metabolic syndrome. It decreases serum levels of oxidized LDL and aortic protein oxidation, as well as reduces atherosclerotic area, in a rabbit model of cholesterol-induced atherosclerosis.2 Norbixin (0.1 and 1 mg/kg per day) reduces mercury-induced DNA damage in isolated rat hepatocytes and leukocytes.3 It also prevents photoreceptor degeneration in an Abca4-/- Rdh8-/- mouse model of age-related macular degeneration (AMD).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. A, R., Agrawal, N., Kumar, H., et al. Norbixin, an apocarotenoid derivative activates PPARγ in cardiometabolic syndrome: Validation by in silico and in vivo experimental assessment. Life Sci. 209, 69-77 (2018).

    2. Somacal, S., Quatrin, A., Ruviaro, A.R., et al. Norbixin, a natural dye that improves serum lipid profile in rabbits and prevents LDL oxidation. Food Res. Int. 159, 111522 (2022).

    3. Barcelos, G.R.M., Grotto, D., Serpeloni, J.M., et al. Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo. Environ. Mol. Mutagen. 53(7), 535-541 (2012).

    4. Fontaine, V., Monteiro, E., M., F., et al. Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease. Aging (Albany N.Y.) 12(7), 6151-6171 (2020).