An internal standard for the quantification of SN-38
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Unlabeled Version(s)
15632SN-38
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SN-38-d3

Item No. 40133

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-ethyl-11-(ethyl-2,2,2-d3)-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS Number
718612-49-8
Synonyms
  • 7-Ethyl-10-Hydroxycamptothecin-d3
  • 7-ethyl-10-hydroxy-20(S)-Camptothecin-d3
Molecular Formula
C22H17D3N2O5
Formula Weight
395.4
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble
SMILES
O=C([C@]1(O)CC)OCC2=C1C=C(C(N=C(C=CC(O)=C3)C3=C4CC([2H])([2H])[2H])=C4C5)N5C2=O
InChi Code
InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1/i1D3
InChi Key
FJHBVJOVLFPMQE-MVTYLIICSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $747

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    Product Description

    SN-38-d3 is intended for use as an internal standard for the quantification of SN-38 (Item No. 15632) by GC- or LC-MS. SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Item No. 14180).1,2 It is formed from irinotecan by carboxylesterases.1 SN-38 (0.1, 1, and 10 µM) induces topoisomerase I-dependent DNA cleavage in a cell-free assay.2 It induces DNA single-strand breaks in HT-29 colorectal adenocarcinoma cells when used at a concentration of 200 nM and cytotoxicity in HT-29 cells (IC50 = 8.8 nM). SN-38 (100 mg/kg per day) reduces tumor volume without affecting body weight in an MX-1 breast cancer mouse xenograft model.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ma, M.K., and McLeod, H.L. Lessons learned from the irinotecan metabolic pathway. Curr. Med. Chem. 10(1), 41-49 (2003).

    2. Tanizawa, A., Fujimori, A., Fujimori, Y., et al. Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials. J. Natl. Cancer Inst. 86(11), 836-842 (1994).

    3. Kawato, Y., Furuta, T., Aonuma, M., et al. Antitumor activity of a camptothecin derivative, CPT-11, against human tumor xenografts in nude mice. Cancer Chemother. Pharmacol. 28(3), 192-198 (1991).