A clickable fluorescent probe
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Cy5-Yne (triethylamine salt)

Item No. 40134

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[5-[1,3-dihydro-3,3-dimethyl-1-[6-oxo-6-(2-propyn-1-ylamino)hexyl]-5-sulfo-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt, compd. with N,N-diethylethanamine
Synonyms
  • Sulfo-Cy5-alkyne
Molecular Formula
C36H43N3O7S2 • C6H15N
Formula Weight
795.1
Purity
≥95%
Emission
680 nm
Excitation
650 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleDMSO: SolubleWater: Slightly soluble
SMILES
OS(C(C=C1)=CC(C2(C)C)=C1N(CCCCCC(NCC#C)=O)C2=CC=CC=CC3=[N+](CC)C4=CC=C(S([O-])(=O)=O)C=C4C3(C)C)(=O)=O.CCN(CC)CC
InChi Code
InChI=1S/C36H43N3O7S2.C6H15N/c1-7-22-37-34(40)17-13-10-14-23-39-31-21-19-27(48(44,45)46)25-29(31)36(5,6)33(39)16-12-9-11-15-32-35(3,4)28-24-26(47(41,42)43)18-20-30(28)38(32)8-2;1-4-7(5-2)6-3/h1,9,11-12,15-16,18-21,24-25H,8,10,13-14,17,22-23H2,2-6H3,(H2-,37,40,41,42,43,44,45,46);4-6H2,1-3H3
InChi Key
ACWIZQUKYQPYQQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $61

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    5 mg

    $273

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    10 mg

    $424

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    25 mg

    $832

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    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    Cy5-Yne is a clickable azido-reactive fluorescent probe.1 It displays excitation/emission maxima of 650/680 nm, respectively. When conjugated to peptides, Cy5-Yne has been used as a pH-independent fluorescent probe for the activity of lysosomal cathepsin proteases in S. typhimurium-infected and bystander bone marrow-derived macrophages (BMDMs).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sanman, L.E., van der Linden, W.A., Verdoes, M., et al. Bifunctional probes of cathepsin protease activity and pH reveal alterations in endolysosomal pH during bacterial infection. Cell Chem. Biol. 23(7), 793-804 (2016).