A fluorescent DNA probe
Related Products
Isomer(s)
16756Hoechst 33258
Technical Support & Resources

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Product Categories

Product Type

Biochemicals
Labeling & Detection
Fluorescent Probes

Research Area

Cancer
Cell Death

Application

Fluorescence

HOE-S 785026

Item No. 40148

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[5-(4-methyl-1-piperazinyl)[2,5′-bi-1H-benzimidazol]-2′-yl]-phenol
CAS Number
132869-83-1
Synonyms
  • m-Hoechst 33258
  • meta-Hoechst 33258
  • m-hydroxy Hoechst 33258
  • meta-hydroxy Hoechst 33258
Molecular Formula
C25H24N6O
Formula Weight
424.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
CN(CC1)CCN1C(C=C2N3)=CC=C2N=C3C4=CC5=C(C=C4)N=C(C6=CC(O)=CC=C6)N5
InChi Code
InChI=1S/C25H24N6O/c1-30-9-11-31(12-10-30)18-6-8-21-23(15-18)29-25(27-21)17-5-7-20-22(14-17)28-24(26-20)16-3-2-4-19(32)13-16/h2-8,13-15,32H,9-12H2,1H3,(H,26,28)(H,27,29)
InChi Key
WOFDIDGQAOQHGY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    10 mg

    $208

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    25 mg

    $439

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    Product Description

    HOE-S 785026 is a fluorescent DNA probe.1 It is cytotoxic to L1210 murine skin lymphocytic leukemia cells (IC50 = 670 nM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Breusegem, S.Y., Sadat-Ebrahimi, S.E., Douglas, K.T., et al. Increased stability and lifetime of the complex formed between DNA and meta-phenyl-substituted Hoechst dyes as studied by fluorescence titrations and stopped-flow kinetics. J. Mol. Biol. 308(40), 649-663 (2001).

    2. Finlay, G.J., and Baguley, B.C. Potentiation by phenylbisbenzimidazoles of cytotoxicity of anticancer drugs directed against topoisomerase II. Eur. J. Cancer 26(5), 586-589 (1990).