A fluorescent substrate for PKA and PKC
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Malantide (trifluoroacetate salt)

Item No. 40150

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-threonyl-L-lysyl-L-arginyl-L-serylglycyl-L-seryl-L-valyl-L-tyrosyl-L-α-glutamyl-L-prolyl-L-leucyl-L-lysyl-L-isoleucine, trifluoroacetate salt
Molecular Formula
C72H124N22O21 • XCF3COOH
Formula Weight
1633.9
Purity
≥98%
Emission
302 nm
Excitation
285 nm
Formulation (Request formulation change)
A solid
Peptide Sequence
RTKRSGSVYEPLKI-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[H]N[C@@H](CCCNC(N)=N)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(NCC(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N1CCC[C@H]1C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C72H124N22O21.C2HF3O2/c1-8-39(6)56(70(114)115)92-62(106)45(18-10-12-28-74)85-63(107)48(32-37(2)3)88-66(110)52-20-15-31-94(52)69(113)47(25-26-54(100)101)87-64(108)49(33-41-21-23-42(98)24-22-41)89-67(111)55(38(4)5)91-65(109)51(36-96)83-53(99)34-82-59(103)50(35-95)90-61(105)46(19-14-30-81-72(78)79)84-60(104)44(17-9-11-27-73)86-68(112)57(40(7)97)93-58(102)43(75)16-13-29-80-71(76)77;3-2(4,5)1(6)7/h21-24,37-40,43-52,55-57,95-98H,8-20,25-36,73-75H2,1-7H3,(H,82,103)(H,83,99)(H,84,104)(H,85,107)(H,86,112)(H,87,108)(H,88,110)(H,89,111)(H,90,105)(H,91,109)(H,92,106)(H,93,102)(H,100,101)(H,114,115)(H4,76,77,80)(H4,78,79,81);(H,6,7)/t39-,40+,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,55-,56-,57-;/m0./s1
InChi Key
XXWDVGVMTSROQS-HDYBVICASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Malantide is a synthetic peptide derived from the β-subunit of human phosphorylase kinase and is a fluorescent substrate for PKA and PKC.1,2 Upon phosphorylation by PKA or PKC, the intrinsic tyrosine fluorescence decreases and can be used to quantify PKA and PKC activity. Malantide displays an emission at 302 nm upon excitation at 285 nm.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Malencik, D.A., and Anderson, S.R. Characterization of a fluorescent substrate for the adenosine 3',5'-cyclic monophosphate-dependent protein kinase. Anal. Biochem. 132(1), 34-40 (1983).

    2. Zhao, Z.H., Malencik, D.A., and Anderson, S.R. Characterization of a new substrate for protein kinase C: Assay by continuous fluorometric monitoring and high performance liquid chromatography. Biochem. Biophys. Res. Commun. 176(3), 1454-1461 (1991).