A STING agonist
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NVS-STG2

Item No. 40159

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[[4-[2-(1,1-dimethylethyl)-5,5-dimethyl-1,3-dioxan-2-yl]phenyl]methyl]amino]-3-methoxy-benzoic acid
CAS Number
3030588-01-0
Molecular Formula
C25H33NO5
Formula Weight
427.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
OC(C1=CC=C(NCC2=CC=C(C3(C(C)(C)C)OCC(C)(C)CO3)C=C2)C(OC)=C1)=O
InChi Code
InChI=1S/C25H33NO5/c1-23(2,3)25(30-15-24(4,5)16-31-25)19-10-7-17(8-11-19)14-26-20-12-9-18(22(27)28)13-21(20)29-6/h7-13,26H,14-16H2,1-6H3,(H,27,28)
InChi Key
CZSPKEVHLRWAFC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    NVS-STG2 is an agonist of stimulator of interferon genes (STING).1 It binds to STING and induces STING activation in a reporter assay (IC50 = 5.2 µM). Intratumoral injection of NVS-STG2 (400 or 800 µg/animal) reduces tumor volume and increases intratumoral IFN-γ levels in a B16.SIY murine melanoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, J., Canham, S.M., Wu, H., et al. Activation of human STING by a molecular glue-like compound. Nat. Chem. Biol. 20(3), 365-372 (2024).