Host: Insect cells • AA: 49-244 • Tag: N-terminal His • MW: 22.8 kDa
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Lymphotoxin-β (cynomolgus monkey, recombinant)

Item No. 40211

Product Insert (PDF)
Technical Information
Synonyms
  • LT-β
  • TNF-C
  • TNFSF3
  • Tumor Necrosis Factor C
  • Tumor Necrosis Factor Ligand Superfamily Member 3
Purity
≥90% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg determined by the LAL endotoxin assay
Source
Recombinant cynomolgus monkey N-terminal His-tagged LT-β expressed in insect cells
Amino Acids
49-244
MW
22.8 kDa
Formulation (Request formulation change)
Lyophilized from sterile 20 mM Tris, pH 7.4, with 500 mM sodium chloride
UniProt Accession №
A0A2K5TTH5
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    50 µg

    $328

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    Cayman Chemical
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    Product Description

    Lymphotoxin-β (LT-β), also known as TNF-C, is a member of the TNF and TNF receptor (TNFR) cytokine superfamily.1 It is a type II transmembrane protein that forms heterotrimers with TNF-β, also known as LT-α, which bind to the LT-β receptor (LT-βR).2,3 LT-β is expressed in T cells, natural killer (NK) cells, B cells, and innate lymphoid cells. Through activation of the LT-βR, LT-β is involved in the development and maintenance of secondary lymphoid organs, as well as the mucosal system, spleen, and bone marrow, host defense, and inflammatory processes.3,4,5 Knockout of Ltb, the gene encoding Lt-β in mice, decreases the number of splenic cytotoxic T lymphocytes and delays viral titer clearance compared with wild-type mice in a model of lymphocytic choriomeningitis virus (LCMV) infection.5 Levels of LT-β are increased in the colons of patients with chronic inflammatory bowel disease and in the tubercular lymph nodes of patients with granulomatous disease.6 Cayman’s Lymphotoxin-β (cynomolgus monkey, recombinant) protein consists of 212 amino acids and has a calculated molecular weight of 22.8 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Idriss, H.T., and Naismith, J.H. TNFα and the TNF receptor superfamily: Structure-function relationship(s). Microsc. Res. Tech. 50(3), 184-195 (2000).

    2. Browning, J.L., Ngam-ek, A., Lawton, P., et al. Lymphotoxin β, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell 72(6), 847-856 (1993).

    3. Dembic, Z. Cytokines in innate immunity. Encyclo. Infect. Immun. 1, 170-192 (2022).

    4. Gommerman, J.L., and Browning, J.L. Lymphotoxin/light, lymphoid microenvironments and autoimmune disease. Nat. Rev. Immunol. 3(8), 642-655 (2003).

    5. Berger, D.P., Naniche, D., Crowley, M.T., et al. Lymphotoxin-β-deficient mice show defective antiviral immunity. Virology 260(1), 136-147 (1999).

    6. Agyekum, S., Church, A., Sohail, M., et al. Expression of lymphotoxin-beta (LT-β) in chronic inflammatory conditions. J. Pathol. 199(1), 115-121 (2003).