Maackiain

Maackiain is a cyclized isoflavonoid that has been found in S. flavescens and has anti-inflammatory and antiallergenic activities.^1,2,3 It inhibits increases in the levels of mRNA encoding the histamine H₁ receptor induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in serum-starved HeLa cells when used at concentrations of 10, 20, or 30 µM and inhibits PMA-induced increases in the levels of mRNA encoding Il-4 in RBL-2H3 cells at 50 or 150 µM.¹ Maackiain decreases LPS-induced increases in nitric oxide (NO) production in RAW 264.7 macrophages (IC₅₀ = 27 µM).² It increases survival in a mouse model of sepsis induced by cecal ligation and puncture (CLP) when administered at doses of 2.5 or 5 mg/kg.³ Maackiain (20 mg/kg per day) reduces the number of sneezes and the extent of nasal redness, swelling, and watery rhinorrhea in a rat model of allergies induced by toluene-2,4-diisocyanate (TDI).¹

WARNING This product is not for human or veterinary use.

1. Mizuguchi, H., Nariai, Y., Kato, S., et al. Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H₁ receptor and interleukin-4 genes. Pharmacol. Res. Perspect. 3(5), e00166 (2015).

2. Lee, J.W., Lee, J.H., Lee, C., et al. Inhibitory constituents of Sophora tonkinensis on nitric oxide production in RAW 264.7 macrophages. Bioorg. Med. Chem. Lett. 25(4), (2015).

3. Bai, X., Zhu, Y., Jie, J., et al. Maackiain protects against sepsis via activating AMPK/Nrf2/HO-1 pathway. Int. Immunopharmacol. 108, 108710 (2022).