An inhibitor of angiogenesis
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NM-3

Item No. 40219

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-hydroxy-6-methoxy-α-methyl-1-oxo-1H-2-benzopyran-3-acetic acid
CAS Number
181427-78-1
Molecular Formula
C13H12O6
Formula Weight
264.2
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C1OC(C(C)C(O)=O)=CC2=C1C(O)=CC(OC)=C2
InChi Code
InChI=1S/C13H12O6/c1-6(12(15)16)10-4-7-3-8(18-2)5-9(14)11(7)13(17)19-10/h3-6,14H,1-2H3,(H,15,16)
InChi Key
BPZCXUROMKDLGX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $351

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    Cayman Chemical
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    Product Description

    NM-3 is a synthetic isocoumarin and an inhibitor of angiogenesis.1 It inhibits S180 cell-induced angiogenesis in an implanted dorsal air sac in mice when administered at doses of 1, 3, and 10 mg/kg. NM-3 (10, 20, and 40 mg/kg) induces intratumoral apoptosis and reduces tumor microvascular density in an SGC-7901 gastric cancer mouse xenograft model.2 It decreases renal levels of VEGF, TGF-β1, and angiopoietin-2 (ANG-2) and renal fibrosis in the db/db transgenic mouse model of diabetes when administered at a dose of 100 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakashima, T., Hirano, S., Agata, N., et al. Inhibition of angiogenesis by a new isocoumarin, NM-3. J. Antibiot. (Tokyo) 52(4), 426-428 (1999).

    2. Ma, J., Zhu, Z., Zhu, J., et al. Study of angiogenesis inhibitor NM-3 on the growth of human gastric cancer. Wannan Yixueyuan Xuebao 25(4), 265-267 (2006).

    3. Ichinose, K., Maeshima, Y., Yamamoto, Y., et al. 2-(8-hydroxy-6-methoxy-1-oxo-1h-2-benzopyran-3-yl) Propionic acid, an inhibitor of angiogenesis, ameliorates renal alterations in obese type 2 diabetic mice. Diabetes 55(5), 1232-1242 (2006).