A metabolite of darunavir
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Parent Compound(s)
15866Darunavir 31083Darunavir (ethanolate)
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Hydroxy Darunavir

Item No. 40225

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[[(4-aminophenyl)sulfonyl](2-hydroxy-2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid, hexahydrofuro[2,3-b]furan-3-yl ester
CAS Number
1130635-75-4
Synonyms
  • R-426857
Molecular Formula
C27H37N3O8S
Formula Weight
563.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
O=C(NC(CC1=CC=CC=C1)C(CN(S(C2=CC=C(N)C=C2)(=O)=O)CC(C)(O)C)O)OC3COC4C3CCO4
InChi Code
InChI=1S/C27H37N3O8S/c1-27(2,33)17-30(39(34,35)20-10-8-19(28)9-11-20)15-23(31)22(14-18-6-4-3-5-7-18)29-26(32)38-24-16-37-25-21(24)12-13-36-25/h3-11,21-25,31,33H,12-17,28H2,1-2H3,(H,29,32)
InChi Key
XGXCRIIMIUNTCF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $402

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    Product Description

    Hydroxy darunavir is a metabolite of the HIV-1 protease inhibitor darunavir (Item Nos. 15866 | 31083).1 It is formed from darunavir by isobutyl aliphatic hydroxylation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vermeir, M., Lachau-Durand, S., Mannens, G., et al. Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects. Drug Metab. Dispos. 37(4), 809-820 (2009).