A microbial metabolite and an ACE inhibitor
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Foroxymithine

Item No. 40228

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-acetyl-N5-formyl-N5-hydroxy-L-ornithyl-N-[3-[(2S,5S)-5-[3-(formylhydroxyamino)propyl]-3,6-dioxo-2-piperazinyl]propyl]-N-hydroxy-L-serinamide
CAS Number
100157-28-6
Molecular Formula
C22H37N7O11
Formula Weight
575.6
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
ON(CCC[C@H](NC(C)=O)C(N[C@@H](CO)C(N(O)CCC[C@@H]1NC([C@@H](NC1=O)CCCN(C=O)O)=O)=O)=O)C=O
InChi Code
InChI=1S/C22H37N7O11/c1-14(33)23-15(5-2-8-27(38)12-31)19(34)26-18(11-30)22(37)29(40)10-4-7-17-21(36)24-16(20(35)25-17)6-3-9-28(39)13-32/h12-13,15-18,30,38-40H,2-11H2,1H3,(H,23,33)(H,24,36)(H,25,35)(H,26,34)/t15-,16-,17-,18-/m0/s1
InChi Key
IQMHGRIOYXVPSE-XSLAGTTESA-N
Origin
Bacterium/Streptomyces nitrosporeus
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $407

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    Product Description

    Foroxymithine is a microbial metabolite that has been found in S. nitrosporeus and an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 7 µg/ml for the bovine lung enzyme).1 It is selective for ACE over nine peptidases (IC50s = >100 µg/ml for all). In vivo, foroxymithine (25 and 50 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats (SHRs). Foroxymithine is also an iron chelator that inhibits the degradation of the tyrosine kinase inhibitor erbstatin (Item No. 37706) and enhances erbstatin-induced reduction of tumor growth in an MCF-7 mouse xenograft model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Umezawa, H., Aoyagi, T., Ogawa, K., et al. Foroxymithine, a new inhibitor of angiotensin-converting enzyme, produced by actinomycetes. J. Antibiot. (Tokyo) 38(12), 1813-1815 (1985).

    2. Toi, M., Mukaida, H., Wada, T., et al. Antineoplastic effect of erbstatin on human mammary and esophageal tumors in athymic nude mice. Eur. J. Cancer 26(6), 722-724 (1990).