A triterpenoid saponin with diverse biological activities
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Raddeanin A

Item No. 40235

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-3-[(O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl)oxy]-olean-12-en-28-oic acid
CAS Number
89412-79-3
Synonyms
  • NSC 382873
Molecular Formula
C47H76O16
Formula Weight
897.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
C[C@@]1(CC[C@]2(CC3)C(O)=O)C([C@]2([H])CC3(C)C)=CC[C@@]4([H])[C@]1(CC[C@](C(C)5C)([H])[C@@]4(CC[C@@H]5O[C@H](OC[C@@H]6O)[C@@H]([C@H]6O)O[C@H](O[C@@H]7CO)[C@@H]([C@H]([C@@H]7O)O)O[C@H](O[C@H]8C)[C@@H]([C@@H]([C@H]8O)O)O)C)C
InChi Code
InChI=1S/C47H76O16/c1-22-30(50)33(53)35(55)38(59-22)62-37-34(54)32(52)26(20-48)60-40(37)63-36-31(51)25(49)21-58-39(36)61-29-12-13-44(6)27(43(29,4)5)11-14-46(8)28(44)10-9-23-24-19-42(2,3)15-17-47(24,41(56)57)18-16-45(23,46)7/h9,22,24-40,48-55H,10-21H2,1-8H3,(H,56,57)/t22-,24-,25-,26+,27-,28+,29-,30-,31-,32+,33+,34-,35+,36+,37+,38-,39-,40-,44-,45+,46+,47-/m0/s1
InChi Key
VQQGPFFHGWNIGX-PPCHTBMASA-N
Origin
Plant/Anemone raddeana
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $43

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    5 mg

    $194

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    10 mg

    $344

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    50 mg

    $1,287

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    Product Description

    Raddeanin A is a triterpenoid saponin that has been found in A. raddeana and has diverse biological activities.1,2,3 It binds to amyloid-β (1-42) (Aβ42; Kd = 27.63 µM).2 Raddeanin A (4 µM) inhibits the invasion and migration of, and induces apoptosis and cell cycle arrest at the G0/G1 phase in, HeLa cervical cancer cells.1 It improves learning and memory in the Morris water maze in mice in the 3xTg model of Alzheimer’s disease when administered at a dose of 10 mg/kg.2 Raddeanin A (50 mg/kg) reduces neurological deficits, lesion volume, edema, and microglia lesion infiltration in a mouse model of acute cerebral hemorrhage induced by intracerebral injection of bacterial collagenase VII.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shen, X., Li, L., He, Y., et al. Raddeanin A inhibits proliferation, invasion, migration and promotes apoptosis of cervical cancer cells via regulating miR-224-3p/Slit2/Robo1 signaling pathway. Aging (Albany NY) 13(5), 7166-7179 (2021).

    2. Liu, M.H., Tang, Y., Qu, L.Q., et al. Raddeanin A isolated from Anemone raddeana Regel improves pathological and cognitive deficits of the mice model of Alzheimer’s disease by targeting β-amyloidosis. Phytomedicine 122, 155121 (2024).

    3. Hei, B., Ouyang, J., Zhou, J., et al. Raddeanin A (RA) reduced acute inflammatory injury in mouse experimental cerebral hemorrhage by suppression of TLR4. Int. J. Med. Sci. 19(8), 1235-1240 (2022).