A diosgenin saponin with diverse biological activities
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Formosanin C

Item No. 40236

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[O-6-deoxy-α-L-mannopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside
CAS Number
50773-42-7
Synonyms
  • NSC 306864
  • Paris Saponin II
  • Polyphyllin B
  • PS II
Molecular Formula
C51H82O20
Formula Weight
1015.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleDMSO: SolubleMethanol: Slightly SolubleWater: Slightly Soluble
SMILES
C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@@]34OC[C@H](C)CC4)([H])C[C@@]1([H])[C@@](CC=C(C5)[C@@]6(CC[C@@H]5O[C@H](O[C@@H]7CO)[C@@H]([C@H]([C@@H]7O[C@H](O[C@H]8C)[C@@H]([C@@H]([C@H]8O[C@H](O[C@H]9C)[C@@H]([C@@H]([C@H]9O)O)O)O)O)O)O[C@H](O[C@H]%10C)[C@@H]([C@@H]([C@H]%10O)O)O)C)([H])[C@]6([H])CC2
InChi Code
InChI=1S/C51H82O20/c1-20-10-15-51(62-19-20)21(2)32-30(71-51)17-29-27-9-8-25-16-26(11-13-49(25,6)28(27)12-14-50(29,32)7)66-48-44(70-46-39(59)36(56)34(54)23(4)64-46)41(61)43(31(18-52)67-48)69-47-40(60)37(57)42(24(5)65-47)68-45-38(58)35(55)33(53)22(3)63-45/h8,20-24,26-48,52-61H,9-19H2,1-7H3/t20-,21+,22+,23+,24+,26+,27-,28+,29+,30+,31-,32+,33+,34+,35-,36-,37+,38-,39-,40-,41+,42+,43-,44-,45+,46+,47+,48-,49+,50+,51-/m1/s1
InChi Key
OZIHYFWYFUSXIS-HDDFSWBLSA-N
Origin
Plant/Rhizoma paridis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

    $1,056

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    Product Description

    Formosanin C is a diosgenin saponin that has been found in P. formosana and has diverse biological activities.1,2,3,4 It is active against C. albicans (MIC = 1 µg/ml) and inhibits C. albicans biofilm formation (MIC = 25 µg/ml).1 Formosanin C (0.625-5 µM) inhibits LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) and nitric oxide (NO) in RAW 264.7 macrophages.2 It induces lipid peroxidation and ferroptosis in MDA-MB-231 breast cancer cells when used at a concentration of 5 µM.3 In vivo, formosanin C (1.5 mg/kg) delays disease onset in a guinea pig model of S-antigen-induced experimental autoimmune uveitis (EAU).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dorsaz, S., Snäkä, T., Favre-Godal, Q., et al. Identification and mode of action of a plant natural product targeting human fungal pathogens. Antimicrob. Agents Chemother. 61(9), e00829-00817 (2017).

    2. Yin, L., Shi, C., Zhang, Z., et al. Formosanin C attenuates lipopolysaccharide-induced inflammation through nuclear factor-κB inhibition in macrophages. Korean J. Physiol. Pharmacol. 25(5), 395-401 (2021).

    3. Chen, H.-C., Tang, H.-H., Hsu, W.-H., et al. Vulnerability of triple-negative breast cancer to saponin formosanin C-induced ferroptosis. Antioxidants (Basel) 11(2), 298 (2022).

    4. Wu, R.-T., Lin, W.-J., Chiang, H.-C., et al. Modulation of experimental autoimmune uveitis with formosanin-C in guinea pigs. J. Ocul. Pharmacol. 6(4), 301-311 (1990).