A fluorescent probe for neurofibrillary tangles
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Neurofibrillary Tangle BODIPY (600/710 nm)

Item No. 40243

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(T-4)-[4-[(1E)-2-[1,8-dihydro-8-(2H-pyrrol-2-ylidene-κN)cyclohepta[b]pyrrol-6-yl-κN]ethenyl]-N,N-dimethylbenzenaminato]difluoro-boron
CAS Number
2301931-35-9
Synonyms
  • NFT BODIPY (600/710 nm)
  • TNIR7-1A
Molecular Formula
C23H20BF2N3
Formula Weight
387.2
Purity
≥95%
Emission
710-774 nm
Excitation
570-600 nm
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
[F][B-]1([F])[N+]2=CC=CC2=C(C=C(/C=C/C3=CC=C(N(C)C)C=C3)C=C4)C5=C4C=C[N]51
InChi Code
InChI=1S/C23H20BF2N3/c1-27(2)20-11-8-17(9-12-20)5-6-18-7-10-19-13-15-29-23(19)21(16-18)22-4-3-14-28(22)24(29,25)26/h3-16H,1-2H3/b6-5+
InChi Key
BXVHPMTVFSTTLF-AATRIKPKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 µg

    $164

    Add
    Product Description

    Neurofibrillary tangle BODIPY (600/710 nm) is a fluorescent probe for neurofibrillary tangles (NFTs).1 It binds to tau-K18 aggregates in a cell-free assay (Kd = 16.8 nM) and is 2.17-fold selective for tau-K18 aggregates over amyloid-β (1-42) (Aβ42) aggregates. NFT BODIPY (600/710 nm) has been used to label NFTs in postmortem hippocampus from patients with Alzheimer’s disease. It has been used to identify tauopathy in vivo and ex vivo in transgenic human tauP301L-expressing mice with a lower signal occurring in the brain of wild-type mice. NFT BODIPY (600/710 nm) displays excitation maxima ranging from 570 to 600 nm and emission maxima ranging from 710 to 774 nm in the solvents methylene chloride, THF, methanol, DMSO, and PBS.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xie, T., Li, Y., Tian, C., et al. Fused cycloheptatriene-BODIPY is a high-performance near-infrared probe to image tau tangles. J. Med. Chem. 65(21), 14527-14538 (2022).