An inhibitor of ecto-5'-nucleotidase
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h-e5'NT Inhibitor 5C

Item No. 40266

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-(1H-indol-3-yl)acetamido)phenyl 4-fluorobenzenesulfonate
Synonyms
  • Human Ecto-5'-nucleotidase Inhibitor 5C
Molecular Formula
C22H17FN2O4S
Formula Weight
424.4
Purity
≥95%
Formulation
A neat solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: SolubleMethanol: Soluble
SMILES
O=C(NC1=CC=CC=C1OS(C2=CC=C(F)C=C2)(=O)=O)CC3=CNC4=CC=CC=C43
InChi Code
InChI=1S/C22H17FN2O4S/c23-16-9-11-17(12-10-16)30(27,28)29-21-8-4-3-7-20(21)25-22(26)13-15-14-24-19-6-2-1-5-18(15)19/h1-12,14,24H,13H2,(H,25,26)
InChi Key
CJYGPPVVPYJXLJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $190

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    10 mg

    $297

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    Product Description

    h-e5'NT Inhibitor 5C is an inhibitor of ecto-5'-nucleotidase, also known as CD73 (IC50s = 0.37 and 1.66 µM for the human and rat enzymes, respectively).1 It also inhibits ectonucleotide pyrophosphate/phosphodiesterase family member 1 (ENPP1), ENPP3, and tissue-non-specific alkaline phosphatase (TNAP; IC50s = 1.12, 1.37, and 1.48 µM, respectively, for the human enzymes).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khan Jadoon, M.S., Pelletier, J., Sévigny, J., et al. Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors. RSC Adv. 13(42), 29496-29511 (2023).