A flavanone with diverse biological activities
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Isomer(s)
14173Naringenin
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Butin

Item No. 40268

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one
CAS Number
21913-99-5
Synonyms
  • 3′,4′,7-Trihydroxyflavanone
Molecular Formula
C15H12O5
Formula Weight
272.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleMethanol: Soluble
SMILES
O=C1C2=CC=C(O)C=C2OC(C3=CC(O)=C(C=C3)O)C1
InChi Code
InChI=1S/C15H12O5/c16-9-2-3-10-12(18)7-14(20-15(10)6-9)8-1-4-11(17)13(19)5-8/h1-6,14,16-17,19H,7H2
InChi Key
MJBPUQUGJNAPAZ-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $50

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    5 mg

    $224

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    10 mg

    $396

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    Product Description

    Butin is a flavanone that has been found in B. monosperma and has diverse biological activities.1,2,3 It induces melanogenesis in B16/F10 melanoma cells when used at a concentration of 1 µM.1 Butin (1-4 µg/ml) decreases DNA damage induced by the actin polymerization inhibitor cytochalasin B (Item No. 11328) in isolated human peripheral blood lymphocytes in a cytokinesis-block micronucleus (CBMN) assay.2 In vivo, butin (5-20 mg/animal) inhibits implantation and decreases the number of pups when administered to pregnant rats.3 It increases uterine weight in ovariectomized rats when administered at a dose of 0.5 mg/animal.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lv, J., Zha, X., Pang, S., et al. Synthesis and melanogenesis evaluation of 3',4',7-trihydroxyflavanone derivatives and characterization of flavanone-BODIPY. Bioorg. Med. Chem. Lett. 25(7), 1607-1610 (2015).

    2. Milosavljevic, S., Djordjevic, I., Mandic, B., et al. Flavonoids of the heartwood of Cotinus coggygria Scop. showing protective effect on human lymphocyte DNA. Nat. Prod. Commun. 16(12), 1-8 (2021).

    3. Bhargava, S.K. Estrogenic and postcoital anticonceptive activity in rats of butin isolated from Butea monosperma seed. J. Ethnopharmacol. 18(1), 95-101 (1986).