8-Shogaol

8-Shogaol is a phenol that has been found in Z. officinale and has diverse biological activities.^1,2,3 It is an inhibitor of TGF-β-activated kinase 1 (TAK1; IC₅₀ = 5.027 nM). 8-Shogaol is also an inhibitor of COX-2 (IC₅₀ = 32 µM).² It reduces IL-17-induced secretion of IL-8 from SW 982 synovial sarcoma cells and Tnf-α from RAW 264.7 macrophages when used at a concentration of 10 µM.¹ 8-Shogaol (5 or 10 µM) decreases TNF-α-induced secretion of IL-6, IL-8, and chemokine (C-C motif) ligand 2 (CCL2) by, and reduces IL-17-induced migration and invasion of, primary human rheumatoid arthritis fibroblast-like synoviocytes. It inhibits migration and invasion induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in MDA-MB-231 breast cancer cells when used at a concentration of 10 µM.³ In vivo, 8-shogaol (30 mg/kg every three days) reduces paw thickness, as well as adjuvant-induced increases in joint space, synovial tissue proliferation, and cartilage damage, and improves gait without reducing body weight in a rat model of adjuvant-induced arthritis (AIA).¹

WARNING This product is not for human or veterinary use.

1. Jo, S., Samarpita, S., Lee, J.S., et al. 8-Shogaol inhibits rheumatoid arthritis through targeting TAK1. Pharmacol. Res. 178, 106176 (2022).

2. van Breemen, R.B., Tao, Y., and Li, W. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia 82(1), 38-43 (2011).

3. Ling, H., Yang, H., Tan, S.H., et al. 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. Br. J. Pharmacol. 161(8), 1763-1777 (2010).