A CXCR7 agonist
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LN6023 (hydrochloride)

Item No. 40287

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(tert-butyl)-1-(3-((7-ethyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino)propyl)piperidine-4-carboxamide, dihydrochloride
Molecular Formula
C20H32N6O2S • 2HCl
Formula Weight
493.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly SolubleWater: Soluble
SMILES
O=C1C=C(CC)N=C2N1N=C(NCCCN3CCC(C(NC(C)(C)C)=O)CC3)S2.Cl.Cl
InChi Code
InChI=1S/C20H32N6O2S.2ClH/c1-5-15-13-16(27)26-19(22-15)29-18(24-26)21-9-6-10-25-11-7-14(8-12-25)17(28)23-20(2,3)4;;/h13-14H,5-12H2,1-4H3,(H,21,24)(H,23,28);2*1H
InChi Key
WPTAIRZLERPUIM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $116

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    1 mg

    $220

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    5 mg

    $693

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    10 mg

    $1,155

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    Product Description

    LN6023 is an agonist of chemokine (C-X-C motif) receptor 7 (CXCR7).1 It induces β-arrestin recruitment in a reporter assay using HEK293T cells expressing human CXCR7 (EC50 = 3.5 µM) but not in HEK293T cells expressing human CXCR4. LN6023 (100 µM) reduces surface levels of P-selectin in isolated and washed human platelets.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bayrak, A., Mohr, F., Kolb, K., et al. Discovery and development of first-in-class ACKR3/CXCR7 superagonists for platelet degranulation modulation. J. Med. Chem. 65(19), 13365-13384 (2022).