An antiviral nucleoside
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2'-Fluoro-2'-deoxycytidine

Item No. 40305

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-deoxy-2′-fluoro-cytidine
CAS Number
10212-20-1
Synonyms
  • 2'-Deoxy-2'-fluorocytidine
  • 2'-FdC
  • NSC 529432
Molecular Formula
C9H12FN3O4
Formula Weight
245.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
F[C@H]1[C@H](N2C(N=C(C=C2)N)=O)O[C@@H]([C@H]1O)CO
InChi Code
InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1
InChi Key
NVZFZMCNALTPBY-XVFCMESISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    2'-Fluoro-2'-deoxycytidine is an antiviral nucleoside.1 It reduces the replication of herpes simplex virus 1 (HSV-1), HSV-2, pseudorabies virus (PRV), or equine abortion virus in virus-infected BHK-21 cells when used at concentrations ranging from 5 to 20 µg/ml. 2'-Fluoro-2'-deoxycytidine inhibits replication of the influenza A subtypes H1N1, H3N2, and H5N1 and influenza B viruses in virus-infected MDCK cells (IC50s = 3.2, 0.59, 1.4, and 1.9 µM, respectively) without inducing cytotoxicity (CC50 = >100 µM for all).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wohlrab, F., Jamieson, A.T., Hay, J., et al. The effect of 2'-fluoro-2'-deoxycytidine on herpes virus growth. Biochim. Biophys. Acta 824(3), 233-242 (1985).

    2. Kumaki, Y., Day, C.W., Smee, D.F., et al. In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections. Antiviral Res. 92(2), 329-340 (2011).