A nucleoside derivative
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5-Formyl-2'-deoxyuridine

Item No. 40306

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-oxo-thymidine
CAS Number
4494-26-2
Synonyms
  • NSC 148297
  • fdUrd
Molecular Formula
C10H12N2O6
Formula Weight
256.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C1N(C=C(C(N1)=O)C=O)[C@@H]2O[C@@H]([C@H](C2)O)CO
InChi Code
InChI=1S/C10H12N2O6/c13-3-5-2-12(10(17)11-9(5)16)8-1-6(15)7(4-14)18-8/h2-3,6-8,14-15H,1,4H2,(H,11,16,17)/t6-,7+,8+/m0/s1
InChi Key
MVORBLZUGBSUNB-XLPZGREQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    250 mg

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    Cayman Chemical
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    Product Description

    5-Formyl-2’-deoxyuridine is a nucleoside derivative.1 It inhibits the proliferation of BHK-21 cells and Ehrlich ascites tumor cells (IC50s = 4 and 6 µM, respectively). 5-Formyl-2’-doxyuridine (1 mM) reduces virus yield in pseudorabies-infected BHK-21 cells. It is also a product of oxidative DNA damage in vitro.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Langen, P., Waschke, S.R., Waschke, K., et al. 5-Formyl-2'-deoxyuridine: Cytostatic and antiviral properties and possible modes of action. Acta Biol. Med. Ger. 35(12), 1625-1633 (1976).

    2. Kasai, H., Kawasaki, Y., and Kawai, K. Pyrimidine ring-opened product from oxidative DNA damage of 5-formyl-2'-deoxyuridine. Chem. Res. Toxicol. 32(4), 737-744 (2019).