An inhibitor of eIF4G1
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SBI-0640756

Item No. 40328

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-6-chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one
Synonyms
  • SBI-756
Molecular Formula
C23H14ClFN2O2
Formula Weight
404.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: SolubleMethanol: Soluble
SMILES
ClC1=CC2=C(C=C1)NC(C(C(/C=C/C3=CC(F)=CN=C3)=O)=C2C4=CC=CC=C4)=O
InChi Code
InChI=1S/C23H14ClFN2O2/c24-16-7-8-19-18(11-16)21(15-4-2-1-3-5-15)22(23(29)27-19)20(28)9-6-14-10-17(25)13-26-12-14/h1-13H,(H,27,29)/b9-6+
InChi Key
VVWGPQZBDQVQRC-RMKNXTFCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $104

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    10 mg

    $193

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    25 mg

    $447

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    Cayman Chemical
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    Product Description

    SBI-0640756 is an inhibitor of eukaryotic translation initiation factor 4 gamma 1 (eIF4G1).1 It inhibits the association of eIF4G1 with the eIF4F complex in UACC-903 melanoma cell lysates in an m7GTP-agarose pull-down assay when used at a concentration of 0.75 µM. SBI-0640756 also inhibits eIF4G1-dependent and -independent mRNA translation in reporter assays using rabbit reticulocyte lysates (IC50s = 3.83 and 4.59 µM, respectively). It reduces the growth of 1205Lu, WM1346, A375, UACC-903, and WM3629 melanoma cells in a concentration-dependent manner. SBI-0640756 (0.5 mg/kg) decreases tumor incidence by 50% in an N-RasQ61K-expressing, Ink4a-/- murine melanoma model. It also decreases tumor volume in an A375 mouse xenograft model when used in combination with the B-RAFV600E inhibitor PLX4720 (Item No. 15142).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Feng, Y., Pinkerton, A.B., Hulea, L., et al. SBI-0640756 attenuates the growth of clinically unresponsive melanomas by disrupting the eIF4F translation initiation complex. Cancer Res. 75(24), 5211-5218 (2015).