A TRPV2 inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

SET2

Item No. 40360

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-furanylmethyl)-3-[[4-(methylpropylamino)-6-(trifluoromethyl)-2-pyrimidinyl]thio]-propanamide
CAS Number
2313525-20-9
Molecular Formula
C17H21F3N4O2S
Formula Weight
402.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(CCSC1=NC(C(F)(F)F)=CC(N(CCC)C)=N1)NCC2=CC=CO2
InChi Code
InChI=1S/C17H21F3N4O2S/c1-3-7-24(2)14-10-13(17(18,19)20)22-16(23-14)27-9-6-15(25)21-11-12-5-4-8-26-12/h4-5,8,10H,3,6-7,9,11H2,1-2H3,(H,21,25)
InChi Key
LZHSWRWIMQRTOP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $109

    Add

    10 mg

    $207

    Add

    25 mg

    $491

    Add

    50 mg

    $872

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    SET2 is an inhibitor of transient receptor potential vanilloid 2 (TRPV2; IC50 = 0.46 µM).1 It selectively inhibits currents induced by the TRP channel modulator 2-APB (Item No. 64970) in a patch-clamp assay using HEK293T cells overexpressing TRPV2 at 0.3 or 1 µM over HEK293T cells overexpressing TRPV1 or TRPV3 at 3 or 10 µM. SET2 (20 µM) reduces migration induced by lysophosphatidic acid (LPA) in PC-3M prostate cancer cells to a similar extent as the LPA receptor 1 (LPA1) antagonist AM966 (Item No. 22048). It also reduces LPA-induced increases in current in a patch-clamp assay using HEK293T cells when used at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chai, H., Cheng, X., Zhou, B., et al. Structure-based discovery of a subtype-selective inhibitor targeting a transient receptor potential vanilloid channel. J. Med. Chem. 62(3), 1373-1384 (2019).