A conditional labeling compound for zinc-binding proteins
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AIZin2

Item No. 40399

Product Insert (PDF)
Technical Information
Formal Name
5-((2-(2-((4-((bis(pyridin-2-ylmethyl)amino)methyl)-1H-imidazole-1-carbonyl)oxy)ethoxy)ethyl)carbamoyl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate
Molecular Formula
C46H40N6O11
Formula Weight
852.8
Formulation (Request formulation change)
A solid
SMILES
O=C(OCCOCCNC(C1=CC(C(OC23C4=C(C=C(OC(C)=O)C=C4)OC5=CC(OC(C)=O)=CC=C53)=O)=C2C=C1)=O)N(C=N6)C=C6CN(CC7=NC=CC=C7)CC8=NC=CC=C8
InChi Code
InChI=1S/C46H40N6O11/c1-29(53)60-35-10-13-39-41(22-35)62-42-23-36(61-30(2)54)11-14-40(42)46(39)38-12-9-31(21-37(38)44(56)63-46)43(55)49-17-18-58-19-20-59-45(57)52-27-34(50-28-52)26-51(24-32-7-3-5-15-47-32)25-33-8-4-6-16-48-33/h3-16,21-23,27-28H,17-20,24-26H2,1-2H3,(H,49,55)
InChi Key
FDNLUSFGGCSOEY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 µg

    $659

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    Product Description

    AIZin2 is a conditional labeling compound for zinc-binding proteins that contains a zinc-coordinating tridentate dipicolylamine group, an electrophile-reactive acyl imidazole moiety, and fluorescein diacetate (Item No. 35701).1 It is attached to proteins via an electrophilic attack on the acyl imidazole moiety when coordinated with protein-associated zinc. AIZin2 has been used to label zinc-binding proteins in HeLa cells for fluorescent detection and for LC-MS/MS proteomic experiments. It displays an emission at 559 nm upon excitation at 473 nm.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miki, T., Awad, M., Nishikawa, Y., et al. A conditional proteomics approach to identify proteins involved in zinc homeostasis. Nat. Methods 13(11), 931-937 (2016).