A nucleoside and inducer of EPC proliferation
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N6-Methyl-2'-deoxyadenosine

Item No. 40407

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-deoxy-N-methyl-adenosine
CAS Number
2002-35-9
Synonyms
  • 6mdA
  • m6dA
  • N6-Methyl-dAdo
  • N6-Methyl-dA
  • N6-Methyldeoxyadenosine
Molecular Formula
C11H15N5O3
Formula Weight
265.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
CNC1=C2C(N([C@@H]3O[C@@H]([C@H](C3)O)CO)C=N2)=NC=N1
InChi Code
InChI=1S/C11H15N5O3/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(18)7(3-17)19-8/h4-8,17-18H,2-3H2,1H3,(H,12,13,14)/t6-,7+,8+/m0/s1
InChi Key
DYSDOYRQWBDGQQ-XLPZGREQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $94

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    25 mg

    $211

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    50 mg

    $374

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    100 mg

    $655

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    Product Description

    N6-Methyl-2'-deoxyadenosine is a nucleoside and inducer of erythroid progenitor cell (EPC) proliferation.1 It stimulates the proliferation of EPCs isolated from mouse fetal livers and colony formation of isolated mouse bone marrow cell-derived progenitor cells when used at concentrations of 10 and 100 µM. N6-Methyl-2'-deoxyadenosine accumulates along promoters and gene coding sequences in activated mouse prefrontal cortical neurons and is associated with activation at the brain-derived neurotrophic factor (Bdnf) P4 promoter, which is essential to the extinction of conditioned fear.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Y., Liang, Z.-Y., and Wang, H.-L. N6-methyl-2'-deoxyadenosine promotes self-renewal of BFU-E progenitor in erythropoiesis. iScience 26(6), 106924 (2023).

    2. Li, X., Zhao, Q., Wei, W., et al. The DNA modification N6-methyl-2'-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction. Nat. Neurosci. 22(4), 534-544 (2019).