An ionizable cationic lipid
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E12CA1A3

Item No. 40415

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hexyl-decanoic acid, 2-[4-(dimethylamino)-1-oxobutoxy]dodecyl ester
CAS Number
2778182-26-4
Molecular Formula
C34H67NO4
Formula Weight
553.9
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
CCCCCCC(CCCCCCCC)C(OCC(CCCCCCCCCC)OC(CCCN(C)C)=O)=O
InChi Code
InChI=1S/C34H67NO4/c1-6-9-12-15-17-18-20-23-27-32(39-33(36)28-24-29-35(4)5)30-38-34(37)31(25-21-14-11-8-3)26-22-19-16-13-10-7-2/h31-32H,6-30H2,1-5H3
InChi Key
PAPHCDVUAFOSMR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

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    10 mg

    $290

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    25 mg

    $482

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    Product Description

    E12CA1A3 is an ionizable cationic lipid (pKa = 6.4) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing E12CA1A3 and encapsulating an mRNA reporter induce luciferase reporter expression in mouse bone marrow-derived dendritic cells (BMDCs) and mice. LNPs containing E12CA1A3 are cleared more rapidly from the liver than LNPs containing DLin-MC3-DMA (Item No. 34364) in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, Y., Hu, Y., Xia, H., et al. Delivery of mRNA vaccine with 1, 2-diesters-derived lipids elicits fast liver clearance for safe and effective cancer immunotherapy. Adv. Healthc. Mater. 13(5), e2302691 (2024).