An ionizable cationic and biodegradable amino lipid
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IR-117-17

Item No. 40420

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(((3-(dibutylamino)propyl)amino)methyl)-6-hydroxyundecane-1,11-diyl (9Z,9'Z,12Z,12'Z)-bis(octadeca-9,12-dienoate)
CAS Number
2940241-38-1
Synonyms
  • A10-LIN
Molecular Formula
C59H110N2O5
Formula Weight
927.5
Purity
≥95%
Formulation (Request formulation change)
A 25 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleEthanol: Soluble
SMILES
CCCCC/C=C\C/C=C\CCCCCCCC(OCCCCCC(C(CCCCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)CNCCCN(CCCC)CCCC)O)=O
InChi Code
InChI=1S/C59H110N2O5/c1-5-9-13-15-17-19-21-23-25-27-29-31-33-35-39-47-58(63)65-53-42-37-38-46-57(62)56(55-60-49-44-52-61(50-11-7-3)51-12-8-4)45-41-43-54-66-59(64)48-40-36-34-32-30-28-26-24-22-20-18-16-14-10-6-2/h17-20,23-26,56-57,60,62H,5-16,21-22,27-55H2,1-4H3/b19-17-,20-18-,25-23-,26-24-
InChi Key
LPCMSGYAOKCGLI-XHFJISOBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $329

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    10 mg

    $625

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    25 mg

    $1,481

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    Product Description

    IR-117-17 is an ionizable cationic and biodegradable amino lipid.1 It has been used in the generation of lipid nanoparticles (LNPs). Nebulized administration of LNPs containing IR-117-17 and the cationic lipid 1,2-dioleoyl-2-trimethylammoniumpropane (1,2-DOTAP; Item No. 15110), among other components, and encapsulating reporter mRNA induce luciferase luminescence in the lung and nasal passages in mice. Nebulized administration of the same LNP formulation but encapsulating Cre mRNA induces the expression of Cre in cells of the large and small airways, as well as alveolar macrophages and epithelial cells, in Ai14 mice engineered to express the fluorescent protein tdTomato upon translation of Cre.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jiang, A.Y., Witten, J., Raji, I.O., et al. Combinatorial development of nebulized mRNA delivery formulations for the lungs. Nat. Nanotechnol. (2023).