An internal standard for the quantification of (±)-epinephrine
Related Products
Unlabeled Version(s)
21245(±)-Epinephrine (hydrochloride)
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(±)-Epinephrine-d3

Item No. 40434

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[1-hydroxy-2-(methyl-d3 amino)ethyl]-1,2-benzenediol
CAS Number
1189977-29-4
Synonyms
  • (±)-Adrenaline-d3
  • DL-Adrenaline-d3
  • DL-Epinephrine-d3
Molecular Formula
C9H10D3NO3
Formula Weight
186.2
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[2H]C([2H])([2H])NCC(C1=CC(O)=C(C=C1)O)O
InChi Code
InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/i1D3
InChi Key
UCTWMZQNUQWSLP-FIBGUPNXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $83

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    10 mg

    $158

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    25 mg

    $372

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    Product Description

    (±)-Epinephrine-d3 is intended for use as an internal standard for the quantification of (±)-epinephrine (Item No. 21245) by GC- or LC-MS. (±)-Epinephrine is a natural neurotransmitter that is released from the adrenal medulla and activates adrenoceptors (Kis = 15, 735, and 3,970 nM for α1A-, β2-, and β1-adrenergic receptors, respectively).1,2,3 Through these receptors, (±)-epinephrine may induce either contraction or relaxation of vascular smooth muscle, depending on adrenoceptor subtype expression.3 Formulations containing (±)-epinephrine have been used in the emergency treatment of severe allergic reactions and the induction and maintenance of mydriasis during intraocular surgery.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rothman, R.B., Vu, N., Partilla, J.S., et al. In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates. J. Pharmacol. Exp. Ther. 307(1), 138-145 (2003).

    2. Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., et al. Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cells. N.-S. Arch. Pharmacol. 369(2), 151-159 (2004).

    3. Ahles, A., and Englehardt, S. Polymorphic variants of adrenoceptors: Pharmacology, physiology, and role in disease. Pharmacol. Rev. 66(3), 598-637 (2014).