An internal standard for the quantification of buspirone
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Buspirone-d8 (hydrochloride)

Item No. 40435

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl-1,1,2,2,3,3,4,4-d8]-8-azaspiro[4.5]decane-7,9-dione, monohydrochloride
CAS Number
1216761-39-5
Synonyms
  • MJ9022-1-d8
Molecular Formula
C21H23D8N5O2 • HCl
Formula Weight
430.0
Purity
≥99% deuterated forms (d1-d8)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
O=C1CC2(CCCC2)CC(N1C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N(CC3)CCN3C4=NC=CC=N4)=O.Cl
InChi Code
InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H/i3D2,4D2,10D2,11D2;
InChi Key
RICLFGYGYQXUFH-WPEKBPPBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $72

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    1 mg

    $129

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    Product Description

    Buspirone-d8 is intended for use as an internal standard for the quantification of buspirone by GC- or LC-MS. Buspirone is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A.1 It binds to the 5-HT1A receptor (IC50 = 5.6 nM) and inhibits forskolin-induced adenylate cyclase activity in primary CA1 hippocampal pyramidal cells. Buspirone inhibits conditioned avoidance responding in rats, as well as inhibits foot shock-induced fighting in mice.2 Formulations containing buspirone have been used in the treatment of generalized anxiety disorder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Taylor, D.P., and Moon, S.L. Buspirone and related compounds as alternative anxiolytics. Neuropeptides 19(Suppl.), 15-19 (1991).

    2. Eison, A.S., and Temple, D.L., Jr. Buspirone: Review of its pharmacology and current perspectives on its mechanism of action. Am. J. Med. 80(3B), 1-9 (1986).