A building block
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4-Hydroxy-1-(2-phenylethyl)piperidine

Item No. 40440

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2-phenylethyl)-4-piperidinol
CAS Number
3518-76-1
Molecular Formula
C13H19NO
Formula Weight
205.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleChloroform: SolubleWater: Slightly soluble
SMILES
OC1CCN(CC1)CCC2=CC=CC=C2
InChi Code
InChI=1S/C13H19NO/c15-13-7-10-14(11-8-13)9-6-12-4-2-1-3-5-12/h1-5,13,15H,6-11H2
InChi Key
KYGMSTKBHJVPJK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $65

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    5 mg

    $295

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    10 mg

    $558

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    25 mg

    $930

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    Product Description

    4-Hydroxy-1-(2-phenylethyl)piperidine is a building block that has been used in the synthesis of ligands of the muscarinic acetylcholine receptor (mAChR) or sigma non-opioid intracellular receptor 1 (σ1 receptor).1,2 It is also a metabolite of the opioids furanyl fentanyl and 4-fluoroisobutyryl fentanyl (FIBF).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tejani-Butt, S.M., Luthin, G.R., Wolfe, B.B., et al. N-substituted derivatives of 4-piperidinyl benzilate: Affinities for brain muscarinic acetylcholine receptors. Life Sci. 47(10), 841-848 (1990).

    2. Prezzavento, O., Arena, E., Parenti, C., et al. Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity. J. Med. Chem. 56(6), 2447-2455 (2013).

    3. Watanabe, S., Vikingsson, S., Roman, M., et al. In vitro and in vivo metabolite identification studies for the new synthetic opioids acetylfentanyl, acrylfentanyl, furanylfentanyl, and 4-fluoro-isobutyrylfentanyl. AAPS J. 19(4), 1102-1122 (2017).