A PROTAC precursor
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VH 032 amide C7 Acid

Item No. 40447

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(8-carboxy-1-oxooctyl)-3-methyl-L-valyl-4R-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide
CAS Number
2172819-76-8
Molecular Formula
C31H44N4O6S
Formula Weight
600.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(CCCCCCCC(O)=O)=O)=O
InChi Code
InChI=1S/C31H44N4O6S/c1-20-27(42-19-33-20)22-14-12-21(13-15-22)17-32-29(40)24-16-23(36)18-35(24)30(41)28(31(2,3)4)34-25(37)10-8-6-5-7-9-11-26(38)39/h12-15,19,23-24,28,36H,5-11,16-18H2,1-4H3,(H,32,40)(H,34,37)(H,38,39)/t23-,24+,28-/m1/s1
InChi Key
WBFMUQOHZVFNHP-FMGHJNRGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

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    50 mg

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    Product Description

    VH 032 amide C7 acid is a precursor in the synthesis of proteolysis-targeting chimeras (PROTACs) that contains a terminal carboxylic acid conjugated via a heptyl linker to VHL ligand 1 (Item No. 21591), which binds to von Hippel-Lindau (VHL) E3 ligase.1 It has been used in the synthesis of PROTACs targeting anaplastic lymphoma kinase (ALK) in cancer cells. Formulations containing dexrazoxane have been used in the treatment of doxorubicin-related cardiomyopathy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, N., Ren, C., Kong, Y., et al. Development of a Brigatinib degrader (SIAIS117) as a potential treatment for ALK positive cancer resistance. Eur. J. Med. Chem. 193, 112190 (2020).