A triantennary GalNAc ASGPR ligand
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Alternative(s)
40456GalNac-L96 (triethylamine salt)
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Product Type

Small Molecule Modulators
Receptor Pharmacology

Research Area

GalNAc-L96

Item No. 40455

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
butanedioic acid, 1-[(3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1,12,19,25-tetraoxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacos-1-yl]-3-pyrrolidinyl] ester
CAS Number
1159408-61-3
Synonyms
  • N-Acetylgalactosamine-L96
  • N-acetyl-D-Galactosamine-L96
Molecular Formula
C121H179N11O45
Formula Weight
2507.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
COC1=CC=C(C=C1)C(C(C=C2)=CC=C2OC)(C3=CC=CC=C3)OC[C@H](C[C@H]4OC(CCC(O)=O)=O)N(C4)C(CCCCCCCCCCC(NC(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]5COC(C)=O)[C@@H]([C@H]([C@H]5OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]6COC(C)=O)[C@@H]([C@H]([C@H]6OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@H](O[C@@H]7COC(C)=O)[C@@H]([C@H]([C@H]7OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C121H179N11O45/c1-76(133)128-108-114(171-85(10)142)111(168-82(7)139)95(70-164-79(4)136)175-117(108)161-61-29-26-37-98(145)122-55-32-58-125-101(148)52-64-158-73-120(74-159-65-53-102(149)126-59-33-56-123-99(146)38-27-30-62-162-118-109(129-77(2)134)115(172-86(11)143)112(169-83(8)140)96(176-118)71-165-80(5)137,75-160-66-54-103(150)127-60-34-57-124-100(147)39-28-31-63-163-119-110(130-78(3)135)116(173-87(12)144)113(170-84(9)141)97(177-119)72-166-81(6)138)131-104(151)40-24-19-17-15-16-18-20-25-41-105(152)132-68-94(174-107(155)51-50-106(153)154)67-91(132)69-167-121(88-35-22-21-23-36-88,89-42-46-92(156-13)47-43-89)90-44-48-93(157-14)49-45-90/h21-23,35-36,42-49,91,94-97,108-119H,15-20,24-34,37-41,50-75H2,1-14H3,(H,122,145)(H,123,146)(H,124,147)(H,125,148)(H,126,149)(H,127,150)(H,128,133)(H,129,134)(H,130,135)(H,131,151)(H,153,154)/t91-,94+,95+,96+,97+,108+,109+,110+,111-,112-,113-,114+,115+,116+,117+,118+,119+/m0/s1
InChi Key
XKEQVRGRWUKTIZ-OLTBZPFJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $185

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    25 mg

    $355

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    50 mg

    $491

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    Product Description

    GalNAc-L96 is a triantennary N-acetylgalactosamine (GalNAc) asialoglycoprotein receptor (ASGPR) ligand.1 It has been used in the synthesis of siRNA-GalNAc conjugates for RNA interference-mediated gene silencing in vitro and in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nair, J.K., Willoughby, J.L., Chan, A., et al. Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing. J. Am. Chem. Soc. 136(49), 16958-16961 (2014).