A PDE5A inhibitor
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PF-00489791

Item No. 40464

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2-ethoxyethyl)-5-(ethylmethylamino)-7-[(4-methyl-2-pyridinyl)amino]-N-(methylsulfonyl)-1H-pyrazolo[4,3-d]pyrimidine-3-carboxamide
CAS Number
853003-48-2
Synonyms
  • PF-489791
  • UK 489791
Molecular Formula
C20H28N8O4S
Formula Weight
476.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMF: Slightly solubleDMSO: Slightly solubleWater: Soluble
SMILES
O=C(C(C1=NC(N(C)CC)=NC(NC2=CC(C)=CC=N2)=C13)=NN3CCOCC)N[S](C)(=O)=O
InChi Code
InChI=1S/C20H28N8O4S/c1-6-27(4)20-23-15-16(19(29)26-33(5,30)31)25-28(10-11-32-7-2)17(15)18(24-20)22-14-12-13(3)8-9-21-14/h8-9,12H,6-7,10-11H2,1-5H3,(H,26,29)(H,21,22,23,24)
InChi Key
ZUHZNKJIJDAJFD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $128

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    10 mg

    $240

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    25 mg

    $559

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    Product Description

    PF-00489791 is an inhibitor of phosphodiesterase 5A (PDE5A; IC50 = 1.9 nM).1 It does not cross the blood-brain barrier in rats. PF-00489791 (10 mg/kg) improves motor scores in a rat model of stroke induced by middle cerebral artery occlusion (MCAO).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Menniti, F.S., Ren, J., Sietsma, D.K., et al. A non-brain penetrant PDE5A inhibitor improves functional recovery after stroke in rats. Restor. Neurol. Neurosci. 30(4), 283-289 (2012).