A NUDT15 inhibitor
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TH-1760

Item No. 40469

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[[4-(1H-indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3H)-benzoxazolone
CAS Number
2567914-01-4
Molecular Formula
C20H18N4O5S
Formula Weight
426.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1OC2=CC(S(=O)(N3CCN(CC3)C(C4=CC=C5NC=CC5=C4)=O)=O)=CC=C2N1
InChi Code
InChI=1S/C20H18N4O5S/c25-19(14-1-3-16-13(11-14)5-6-21-16)23-7-9-24(10-8-23)30(27,28)15-2-4-17-18(12-15)29-20(26)22-17/h1-6,11-12,21H,7-10H2,(H,22,26)
InChi Key
HNCVDRFFJZJQRW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $65

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    10 mg

    $117

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    25 mg

    $260

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    50 mg

    $455

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    Product Description

    TH-1760 is an inhibitor of nucleotide triphosphate diphosphatase NUDT15 (IC50 = 25 nM).1 It is selective for NUDT15 over a panel of additional Nudix family hydrolases and nucleotide pyrophosphatases at 100 µM, as well as a panel of 44 kinases at 10 µM. TH-1760 enhances thiopurine-induced cell death in NB4 and HL-60 cancer cells in a NUDT15-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, S.M., Desroses, M., Hagenkort, A., et al. Development of a chemical probe against NUDT15. Nat. Chem. Biol. 16(10), 1120-1128 (2020).