A 5-HT2 receptor agonist
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AL 34662 (formate)

Item No. 40489

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(2S)-2-aminopropyl]-1H-indazol-6-ol, monoformic acid
Molecular Formula
C10H13N3O • CH2O2
Formula Weight
237.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=CO.OC1=CC=C(C=NN2C[C@@H](N)C)C2=C1
InChi Code
InChI=1S/C10H13N3O.CH2O2/c1-7(11)6-13-10-4-9(14)3-2-8(10)5-12-13;2-1-3/h2-5,7,14H,6,11H2,1H3;1H,(H,2,3)/t7-;/m0./s1
InChi Key
QPFALLGPBFXMAX-FJXQXJEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $104

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    10 mg

    $165

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    50 mg

    $379

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    Product Description

    AL 34662 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2.1 It selectively binds to 5-HT2 receptors (IC50 = 1.5 and 0.77 nM in isolated and washed human or rat cerebral cortex homogenates, respectively) over a panel of 19 neurotransmitter and steroid receptors at 10 µM. AL 34662 induces calcium mobilization in a reporter assay using primary human ciliary muscle cells (EC50 = 140 nM). It reduces intraocular pressure (IOP) in a cynomolgus monkey model of trabeculoplasty-induced ocular hypertension when administered at doses of 100 or 300 µg/eye.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharif, N.A., McLaughlin, M.A., and Kelly, C.R. AL-34662: A potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J. Ocul. Pharmacol. Ther. 23(1), 1-13 (2007).