An ionizable cationic lipid
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Lipid 88

Item No. 40493

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tetrakis(2-((((2-butyloctyl)oxy)carbonyl)oxy)ethyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate
CAS Number
2982842-99-7
Molecular Formula
C79H147N3O20
Formula Weight
1459.0
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CCCCCCC(CCCC)COC(OCCOC(CCN(CCC(OCCOC(OCC(CCCC)CCCCCC)=O)=O)CCCN(C)CCCN(CCC(OCCOC(OCC(CCCC)CCCCCC)=O)=O)CCC(OCCOC(OCC(CCCC)CCCCCC)=O)=O)=O)=O
InChi Code
InChI=1S/C79H147N3O20/c1-10-18-26-30-40-68(36-22-14-5)64-99-76(87)95-60-56-91-72(83)44-52-81(53-45-73(84)92-57-61-96-77(88)100-65-69(37-23-15-6)41-31-27-19-11-2)50-34-48-80(9)49-35-51-82(54-46-74(85)93-58-62-97-78(89)101-66-70(38-24-16-7)42-32-28-20-12-3)55-47-75(86)94-59-63-98-79(90)102-67-71(39-25-17-8)43-33-29-21-13-4/h68-71H,10-67H2,1-9H3
InChi Key
JUWROHWTUPFLCX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $86

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    5 mg

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    10 mg

    $472

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    Cayman Chemical
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    Product Description

    Lipid 88 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing lipid 88 and encapsulating mRNA encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein increase anti-spike glycoprotein IgG titers in bronchoalveolar lavage fluid (BALF), as well as increase the percentage of CD8+, CD8+CD44+, CD4+, and CD4+CD44+ T cells in the lungs and spleen, in mice after two doses three weeks apart. LNPs containing lipid 88 and encapsulating mRNA encoding SARS-CoV-2 spike glycoprotein inhibit reductions in body weight, increase serum levels of anti-spike glycoprotein IgG and IgA titers, and reduce lung and nasal wash viral titers in a hamster model of SARS-CoV-2 Omicron BQ.1 subvariant infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ye, Z., Bonam, S.R., McKay, L.G.A., et al. Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants. Proc. Natl. Acad. Sci. USA 120(52), e2311752120 (2023).