An ionizable cationic lipid
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Ionizable Lipid 4

Item No. 40496

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9,12-octadecadienoic acid, (9Z,12Z)-1,1′-[2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]-1,3-propanediyl] ester
CAS Number
1799316-81-6
Molecular Formula
C48H85NO7
Formula Weight
788.2
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
CCCCC/C=C\C/C=C\CCCCCCCC(OCC(COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(OCCCN(CC)CC)=O)=O
InChi Code
InChI=1S/C48H85NO7/c1-5-9-11-13-15-17-19-21-23-25-27-29-31-33-35-38-46(50)54-42-45(44-56-48(52)53-41-37-40-49(7-3)8-4)43-55-47(51)39-36-34-32-30-28-26-24-22-20-18-16-14-12-10-6-2/h15-18,21-24,45H,5-14,19-20,25-44H2,1-4H3/b17-15-,18-16-,23-21-,24-22-
InChi Key
CKINQEPXJRAYIN-MLLZQYMOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $196

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    25 mg

    $464

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    50 mg

    $818

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    Cayman Chemical
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    Product Description

    Ionizable lipid 4 is an ionizable cationic lipid (pKa = 6.1) and a hydrogen peroxide-induced rearrangement product of the cationic lipid CA-lipid 5.1 Charge-altering lipid nanoparticles (CALNPs) containing CA-lipid 5 and encapsulating siRNA against EGFP undergo hydrogen peroxide-induced removal of the phenylboronic acid groups from CA-lipid 5 in MCF-7 cells in vitro, generating ionizable lipid 4-containing LNPs with reduced positive charges at physiological pH, facilitating intracellular siRNA release and gene silencing. LNPs containing ionizable lipid 4 and encapsulating siRNA against PLK1 reduce tumor volume in an MCF-7 mouse xenograft model less effectively than CALNPs containing CA-lipid 5.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, F., Lei, L., Wang, X., et al. Engineering cell-selective charge-altering lipid nanoparticles for efficient siRNA delivery in vivo. CCS Chemistry Online ahead of print, (2024).