For immunochemical detection of oxidized phospholipids
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Oxidized Phospholipid Monoclonal Antibody (Clone 509)

Item No. 40508

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • OxPL
Immunogen
Oxidized phospholipids and oxidized lipoprotein
Clone Designation
509
Formulation (Request formulation change)
100 µg protein L-purified mouse IgM
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Mouse
Isotype
IgM
Applications
ELISA, IHC, WB
Cross Reactivity
(+) OxLDL(+) OxPE(-) LDL
Species Reactivity
(Independent) Species
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $439

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    Product Description

    Oxidized phospholipids (OxPLs) are a class of lipid mediators involved in diverse physiological and pathological processes.1 In particular, fragmented OxPLs on the surface of LDL can be formed via β-scission of the sn-2 fatty acid fragment on the glycerol backbone and are immunogenic.1,2 The 509 OxPL antibody clone binds to oxidized LDL (OxLDL) and selectively binds to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine (OxPAPE) over PAPE, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC), PAPC, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphoserine (OxPAPS), PAPS, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidic acid (OxPAPA), and PAPA.3 Cayman’s Oxidized Phospholipid Monoclonal Antibody (Clone 509) can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications. The original 509 antibody was generated via immunization of mice with OxPAPC and oxLDL with Freund’s adjuvant.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bochkov, V., Gesslbauer, B., Mauerhofer, C., et al. Pleiotropic effects of oxidized phospholipids. Free Radic. Biol. Med. 111, 6-24 (2017).

    2. Hörkkö, S., Miller, E., Dudl, E., et al. Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein. J. Clin. Invest. 98(3), 815-825 (1996).

    3. Bochkov, V., Schoenenberger, A.W., Oskolkova, O., et al. Novel immune assay for quantification of plasma protective capacity against oxidized phospholipids. Biomark. Med. 10(8), 797-810 (2016).