An ionizable cationic lipid
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YHS-12

Item No. 40510

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-N1,N4-bis[2-(didodecylamino)ethyl]-2-butenediamide
CAS Number
2959463-68-2
Molecular Formula
C56H112N4O2
Formula Weight
873.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly soluble: 1-10 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
CCCCCCCCCCCCN(CCNC(/C=C/C(NCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)=O)CCCCCCCCCCCC
InChi Code
InChI=1S/C56H112N4O2/c1-5-9-13-17-21-25-29-33-37-41-49-59(50-42-38-34-30-26-22-18-14-10-6-2)53-47-57-55(61)45-46-56(62)58-48-54-60(51-43-39-35-31-27-23-19-15-11-7-3)52-44-40-36-32-28-24-20-16-12-8-4/h45-46H,5-44,47-54H2,1-4H3,(H,57,61)(H,58,62)/b46-45+
InChi Key
PHYKVTFJFHNIHG-XVIFHXHVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    YHS-12 is an ionizable cationic lipid (pKa = 6.506) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo.1 LNPs containing YHS-12 and the macrophage targeting peptide CRVLRSGSC and encapsulating mRNA encoding chimeric antigen receptor targeting methicillin-resistant S. aureus (MRSA) and siRNA targeting caspase-11 increase the phagocytosis rate of MRSA in RAW 264.7 macrophages and primary mouse bone marrow-derived macrophages (BMDMs). Intravenous administration of these LNPs decreases blood bacterial burden and increases survival in a model of sepsis using cyclophosphamide-induced immunosuppressed mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tang, C., Jing, W., Han, K., et al. mRNA-laden lipid-nanoparticle-enabled in situ CAR-macrophage engineering for the eradication of multidrug-resistant bacteria in a sepsis mouse model. ACS Nano 18(3), 2261-2278 (2024).