A disulfide bond-containing ionizable cationic lipid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PPPDA-O16B

Item No. 40517

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
bis(2-(dodecyldisulfaneyl)ethyl) 3,3'-(propylazanediyl)dipropionate
CAS Number
3097638-12-2
Molecular Formula
C37H73NO4S4
Formula Weight
724.2
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
CCCN(CCC(OCCSSCCCCCCCCCCCC)=O)CCC(OCCSSCCCCCCCCCCCC)=O
InChi Code
InChI=1S/C37H73NO4S4/c1-4-7-9-11-13-15-17-19-21-23-32-43-45-34-30-41-36(39)25-28-38(27-6-3)29-26-37(40)42-31-35-46-44-33-24-22-20-18-16-14-12-10-8-5-2/h4-35H2,1-3H3
InChi Key
YVPNKVLDJGNNNV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $130

    Add

    10 mg

    $247

    Add

    25 mg

    $585

    Add
    Cayman Chemical
    Ionizable Lipids – Your Path from R&D to GMP

    Seamlessly bridge your LNP discovery journey from RUO to bulk GLP-tox and GMP excipient-grade material.

    Explore CGMP Lipid Services
    Product Description

    PPPDA-O16B is a disulfide bond-containing ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for plasmid delivery in vitro and in vivo.1 LNPs containing PPPDA-O16B and encapsulating plasmids encoding Ras/Rap1-specific endopeptidase (RRSP) increase RRSP levels and decrease Ras levels in, and reduce the viability of, HeLa cervical cancer cells. LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP selectively localize to tumors over the heart, liver, spleen, lungs, and kidneys, as well as decrease tumor volume without reducing body weight, in an HCT116 colorectal cancer mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, W., Shao, L., Liu, J., et al. Intracellular delivery of bacterial effectors for cancer therapy using biodegradable lipid nanoparticles. Biomater. Sci. 11(9), 3172-3179 (2023).