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5,6-dichloro Brorphine

Item No. 40532

Product Insert (PDF)Technical Brief (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • SR-14968
Technical Information
Formal Name
1-[1-[1-(4-bromophenyl)ethyl]-4-piperidinyl]-5,6-dichloro-1,3-dihydro-2H-benzimidazol-2-one
CAS Number
2133455-40-8
Molecular Formula
C20H20BrCl2N3O
Formula Weight
469.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
BrC1=CC=C(C(C)N2CCC(N3C(NC4=C3C=C(Cl)C(Cl)=C4)=O)CC2)C=C1
InChi Code
InChI=1S/C20H20BrCl2N3O/c1-12(13-2-4-14(21)5-3-13)25-8-6-15(7-9-25)26-19-11-17(23)16(22)10-18(19)24-20(26)27/h2-5,10-12,15H,6-9H2,1H3,(H,24,27)
InChi Key
DJSSLECNUQMYKG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    5,6-dichloro Brorphine (Item No. 40532) is an analytical reference standard categorized as an opioid.1 5,6-dichloro Brorphine induces antinociception, antinociceptive tolerance, naloxone-precipitated withdrawal symptoms, and conditioned place preference in mice.2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stahl, E.L., Schmid, C.L., Acevedo-Canabal, A., et al. G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists. Proc. Natl. Acad. Sci. USA 118(48), e2102178118 (2021).

    2. Kudla, L., Bugno, R., Podlewska, S., et al. Comparison of an addictive potential of μ-opioid receptor agonists with G protein bias: Behavioral and molecular modeling studies. Pharmaceutics 14(1), 55 (2021).