Active • Host: E. coli strain BL21 Star (DE3) • AA: 16-315 • Tag: C-terminal His • MW: 37.3 kDa
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β-(1->4)-N-Acetylgalactosaminyltransferase (CgtA-II) (C. jejuni, recombinant)

Item No. 40540

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
β-(1->4)-N-Acetylgalactosaminyltransferase (CgtA-II) (C. jejuni, recombinant)
Synonyms
  • β-1,4-N-Acetylgalactosaminyltransferase (CjCgtA-II)
  • CgtA-II
  • CjCgtA-II
  • β1-4GalNAcT
Purity
Clarified lysate
Source
Active recombinant C. jejuni C-terminal His-tagged CgtA-II expressed in E. coli strain BL21 Star (DE3)
Amino Acids
16-315 (truncate)
MW
37.32 kDa
Formulation (Request formulation change)
50 mM HEPES, with 20 mM magnesium dichloride and 5% glycerol
UniProt Accession №
Q934C5
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    1 mg

    $528

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    Cayman Chemical
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    Product Description

    β-(1->4)-N-Acetylgalactosaminyltransferase (β1-4GalNAcT) from C. jejuni is a glycosyltransferase involved in lipooligosaccharide synthesis.1,2 There are three variants of C. jejuni β1-4GalNAcT: CgtA, CgtA-I, and CgtA-II, which are functionally homologous despite the sequences being only 34% conserved.2,3 CgtA-II transfers N-acetylgalactosamine (GalNAc) to mono- or disialylated galactose moieties.3 CgtA-II has been used in the semisynthesis of ganglioside GM2 and -GD2 glycans.1 Cayman’s β-(1->4)-N-Acetylgalactosaminyltransferase (CgtA-II) (C. jejuni, recombinant) protein can be used for biosynthesis applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, H., Li, Y., Zeng, J., et al. Sequential one-pot multienzyme chemoenzymatic synthesis of glycosphingolipid glycans. The Journal of Organic Chemistry 81(22), 10809-10824 (2016).

    2. Gilbert, M., Karwaski, M.F., Bernatchez, S., et al. The genetic bases for the variation in the lipo-oligosaccharide of the mucosal pathogen, Campylobacter jejuni. Biosynthesis of sialylated ganglioside mimics in the core oligosaccharide. The Journal of Biological Chemisty 277(1), 327-337 (2002).

    3. Gilbert, M., Parker, C.T., and Moran, A.P. Campylobacter jejuni lipooligosaccharides: Structures and biosynthesis. Campylobacter (2008).