An ionizable cationic lipid
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4-O10b1

Item No. 40603

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tetra(decan-2-yl) 3,3',3'',3'''-((piperazine-1,4-diylbis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate
Molecular Formula
C62H120N4O8
Formula Weight
1049.7
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
CC(CCCCCCCC)OC(CCN(CCC(OC(C)CCCCCCCC)=O)CCCN1CCN(CCCN(CCC(OC(C)CCCCCCCC)=O)CCC(OC(C)CCCCCCCC)=O)CC1)=O
InChi Code
InChI=1S/C62H120N4O8/c1-9-13-17-21-25-29-35-55(5)71-59(67)39-47-63(48-40-60(68)72-56(6)36-30-26-22-18-14-10-2)43-33-45-65-51-53-66(54-52-65)46-34-44-64(49-41-61(69)73-57(7)37-31-27-23-19-15-11-3)50-42-62(70)74-58(8)38-32-28-24-20-16-12-4/h55-58H,9-54H2,1-8H3
InChi Key
KGPSHYZXZZTKHI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $83

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    10 mg

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    50 mg

    $578

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    Cayman Chemical
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    Product Description

    4-O10b1 is an ionizable cationic lipid (pKa = 5.148) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA in vitro and in vivo.1 LNPs containing 4-O10b1, conjugated to an antibody targeting the mouse macrophage marker F4/80 (anti-F4/80), and encapsulating siRNA targeting the mRNA encoding TGF-β-activated kinase 1 (Tak1) inhibit poly(I:C)-induced production of IL-1β, IL-6, and TNF-α in RAW 264.7 macrophages. In vivo, intranasal administration of these LNPs decreases lung injury and reduces total protein levels and myeloperoxidase (Mpo) activity in bronchoalveolar lavage fluid (BALF) in a mouse model of influenza A-induced pneumonia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, G., Xue, L., Geisler, H.C., et al. Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery. Proc. Natl. Acad. Sci. USA 121(7), e2314747121 (2024).