An ionizable cationic lipid
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80-O18

Item No. 40611

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-(dimethylamino)propyl]-N-[3-(octadecyloxy)-3-oxopropyl]-β-alanine, octadecyl ester
CAS Number
1638334-27-6
Molecular Formula
C47H94N2O4
Formula Weight
751.3
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(OCCCCCCCCCCCCCCCCCC)CCN(CCC(OCCCCCCCCCCCCCCCCCC)=O)CCCN(C)C
InChi Code
InChI=1S/C47H94N2O4/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-44-52-46(50)38-42-49(41-37-40-48(3)4)43-39-47(51)53-45-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h5-45H2,1-4H3
InChi Key
LWTRCSOOEXKOHW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $184

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    25 mg

    $384

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    50 mg

    $666

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    Cayman Chemical
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    Product Description

    80-O18 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for use in vitro.1 An LNP complex containing 80-O18 and a Cre-GFP fusion protein tagged with one of three assay-specific chloroalkane tags displays high total cellular uptake and functional delivery in reporter assays using HeLa-DsRed cells, as well as cytosolic delivery in a chloroalkane penetration assay (CAPA) screen using HeLa-HGM cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, J., Zhang, S., Li, Y., et al. Investigating the cytosolic delivery of proteins by lipid nanoparticles using the chloroalkane penetration assay. Biochemistry (2024).