A prodrug form of 6-diazo-5-oxo-L-nor-leucine
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Active Metabolite(s)
175806-diazo-5-oxo-L-nor-Leucine
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JHU083

Item No. 40642

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-leucyl-6-diazo-5-oxo-L-norleucine, ethyl ester
CAS Number
1998725-11-3
Molecular Formula
C14H24N4O4
Formula Weight
312.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
[N-]=[N+]=CC(CC[C@@H](C(OCC)=O)NC([C@H](CC(C)C)N)=O)=O
InChi Code
InChI=1S/C14H24N4O4/c1-4-22-14(21)12(6-5-10(19)8-17-16)18-13(20)11(15)7-9(2)3/h8-9,11-12H,4-7,15H2,1-3H3,(H,18,20)/t11-,12-/m0/s1
InChi Key
YZRCHOFKIPHQBW-RYUDHWBXSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    500 µg

    $149

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    1 mg

    $283

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    Cayman Chemical
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    Product Description

    JHU083 is a prodrug form of the glutaminase inhibitor 6-diazo-5-oxo-L-nor-leucine (Item No. 17580).1 It decreases tumor volume, increases tumor microenvironment (TME) levels of Tnf-secreting macrophages, and increases survival in a B6CaP murine prostate cancer model.1 JHU083 increases tumor infiltration by Cd8+ T cells in a UN-SCC680 murine lung squamous cell carcinoma model.2 It also reduces granuloma area and lung weight and increases survival in M. tuberculosis-infected mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Praharaj, M., Shen, F., Lee, A.J., et al. Metabolic reprogramming of tumor-associated macrophages using glutamine antagonist JHU083 drives tumor immunity in myeloid-rich prostate and bladder cancers. Cancer Immunol. Res. 12(7), 854-875 (2024).

    2. Huang, M., Xiong, D., Pan, J., et al. Targeting glutamine metabolism to enhance immunoprevention of EGFR-driven lung cancer. Adv. Sci. (Weinh) 9(26), e2105885 (2022).

    3. Parveen, S., Shen, J., Lun, S., et al. Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis. Nat. Commun. 14(1), 7427 (2023).