An NLRP3 inflammasome agonist
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BMS 986299

Item No. 40652

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[4-amino-7-(1H-pyrazol-3-yl)-3H-imidazo[4,5-c]quinolin-2-yl]methyl]-N-ethyl-acetamide
CAS Number
2242952-69-6
Molecular Formula
C18H19N7O
Formula Weight
349.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlEthanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C)N(CC)CC1=NC2=C(N1)C3=C(C=C(C4=NNC=C4)C=C3)N=C2N
InChi Code
InChI=1S/C18H19N7O/c1-3-25(10(2)26)9-15-22-16-12-5-4-11(13-6-7-20-24-13)8-14(12)21-18(19)17(16)23-15/h4-8H,3,9H2,1-2H3,(H2,19,21)(H,20,24)(H,22,23)
InChi Key
UHNRLQRZRNKOKU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    BMS 986299 is an agonist of the NOD-like receptor protein 3 (NLRP3) inflammasome .1 It induces IL-1β secretion from mouse macrophages expressing the human NLRP3 inflammasome (EC50 = 1.28 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Glick, G., Ghosh, S., Roush, W.R., et al. Substututed imidazo-quinolines as NLRP3 modulators. (2018).