A nitroxyl donor
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Cimlanod

Item No. 40660

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-hydroxy-5-methyl-2-furansulfonamide
CAS Number
1620330-72-4
Synonyms
  • BMS-986231
  • CXL-1427
Molecular Formula
C5H7NO4S
Formula Weight
177.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
CC1=CC=C(S(NO)(=O)=O)O1
InChi Code
InChI=1S/C5H7NO4S/c1-4-2-3-5(10-4)11(8,9)6-7/h2-3,6-7H,1H3
InChi Key
LIXKIXWSKOENAB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $163

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    10 mg

    $266

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    25 mg

    $510

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    Product Description

    Cimlanod is a nitroxyl donor.1 In vivo, cimlanod (7 µg/kg/min infusion for four hours) reduces mean arterial pressure (MAP) and systemic vascular resistance and increases cardiac output at four hours post infusion in a dog model of microembolism-induced heart failure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hartman, J.C., del Rio, C.L., Reardon, J.E., et al. Intravenous infusion of the novel HNO donor BMS-986231 is associated with beneficial inotropic, lusitropic, and vasodilatory properties in 2 canine models of heart failure. JACC Basic Transl. Sci. 3(5), 625-638 (2018).