An alkaloid with enzyme inhibitory activity
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(−)-Narwedine

Item No. 40744

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(8aS)-4aS,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one
CAS Number
510-77-0
Synonyms
  • Galanthaminone
Molecular Formula
C17H19NO3
Formula Weight
285.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
CN1CC(C=CC(OC)=C2O[C@@]34[H])=C2[C@@]4(C=CC(C3)=O)CC1
InChi Code
InChI=1S/C17H19NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,14H,7-10H2,1-2H3/t14-,17-/m0/s1
InChi Key
QENVUHCAYXAROT-YOEHRIQHSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $87

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    5 mg

    $326

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    10 mg

    $609

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    25 mg

    $1,087

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    Product Description

    (−)-Narwedine is an alkaloid that has been found in N. pseudonarcissus and has enzyme inhibitory activity.1 It is an inhibitor of acetylcholineesterase (AChE), butyrylcholinesterase (BChE), and prolyl endopeptidase (IC50s = 281, 911, and 907 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hulcová, D., Maříková, J., Korábečný, J., et al. Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer’s disease. Phytochemistry 165, 112055 (2019).