An ionizable cationic lipid
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11-10-8

Item No. 40747

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
((2-(pyrrolidin-1-yl)ethyl)azanediyl)bis(decane-1,2-diyl) dioctanoate
CAS Number
3078748-21-4
Molecular Formula
C42H82N2O4
Formula Weight
679.1
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
O=C(CCCCCCC)OC(CCCCCCCC)CN(CCN1CCCC1)CC(CCCCCCCC)OC(CCCCCCC)=O
InChi Code
InChI=1S/C42H82N2O4/c1-5-9-13-17-21-23-29-39(47-41(45)31-25-19-15-11-7-3)37-44(36-35-43-33-27-28-34-43)38-40(30-24-22-18-14-10-6-2)48-42(46)32-26-20-16-12-8-4/h39-40H,5-38H2,1-4H3
InChi Key
LRBLCOLXDIPVSZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    11-10-8 is an ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for mRNA delivery in vivo.1 LNPs containing 11-10-8 and encapsulating mRNA encoding the Cas9 nuclease and small-guide RNA (sgRNA) targeting transthyretin (TTR), a thyroid hormone carrier protein, decrease serum levels of TTR in mice. LNPs containing 11-10-8 and encapsulating mRNA encoding human fibroblast growth factor 21 (hFGF21) increase serum levels of hFGF21, decrease body and liver weights, and reduce the liver steatosis score in a mouse model of obesity induced by a high-fat diet.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Han, X., Xu, J., Xu, Y., et al. In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors. Nat. Commun. 15(1), 1762 (2024).