A Nav1.8 inhibitor
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Suzetrigine

Item No. 40799

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-2-pyridinecarboxamide
CAS Number
2649467-58-1
Synonyms
  • VX-548
Molecular Formula
C21H20F5N3O4
Formula Weight
473.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NC1=CC=NC(C(N)=O)=C1)[C@H]2[C@H](C3=C(OC)C(F)=C(F)C=C3)[C@H](C)[C@](C)(C(F)(F)F)O2
InChi Code
InChI=1S/C21H20F5N3O4/c1-9-14(11-4-5-12(22)15(23)16(11)32-3)17(33-20(9,2)21(24,25)26)19(31)29-10-6-7-28-13(8-10)18(27)30/h4-9,14,17H,1-3H3,(H2,27,30)(H,28,29,31)/t9-,14-,17+,20+/m0/s1
InChi Key
XSQUJFKRXZMOKA-PAFIKIDNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $86

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    5 mg

    $215

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    10 mg

    $344

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    Product Description

    Suzetrigine is an inhibitor of voltage-gated sodium channel 1.8 (Nav1.8; IC50 = 0.7 nM for the human channel).1 It is selective for Nav1.8 over a panel of eight additional voltage-gated sodium channels (IC50s = >10,000 nM for all).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jones, J., Correll, D.J., Lechner, S.M., et al. Selective inhibition of NaV1.8 with VX-548 for acute pain. N. Engl. J. Med. 389(5), 393-405 (2023).