An ionizable cationic lipid
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SIL Lipid

Item No. 40801

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N′,N′′-(nitrilotri-2,1-ethanediyl)tris[N-methyl-β-alanine, 1,1′,1′′-tridodecyl ester
CAS Number
1566559-79-2
Molecular Formula
C54H108N4O6
Formula Weight
909.5
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CN(CCC(OCCCCCCCCCCCC)=O)CCN(CCN(C)CCC(OCCCCCCCCCCCC)=O)CCN(CCC(OCCCCCCCCCCCC)=O)C
InChi Code
InChI=1S/C54H108N4O6/c1-7-10-13-16-19-22-25-28-31-34-49-62-52(59)37-40-55(4)43-46-58(47-44-56(5)41-38-53(60)63-50-35-32-29-26-23-20-17-14-11-8-2)48-45-57(6)42-39-54(61)64-51-36-33-30-27-24-21-18-15-12-9-3/h7-51H2,1-6H3
InChi Key
FMMMNNIOHXMPJP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $189

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    10 mg

    $356

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    25 mg

    $785

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    Cayman Chemical
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    Product Description

    SIL lipid is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA in vitro.1 LNPs containing SIL lipid and encapsulating siRNA targeting mRNA encoding the purinergic P2X7 receptor decrease protein levels of the purinergic P2X7 receptor, reduce migration in a wound healing assay, and induce apoptosis and necrosis in 4T1 breast cancer cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kiaie, S.H., Zangi, A.R., Sheibani, M., et al. Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells. Purinergic Signal (2024).